![]() Received: DecemAccepted: Published: June 19, 2015Ĭopyright: © 2015 Reddy et al. Gray, University of Cape Town, SOUTH AFRICA FNA and lymph node biopsy had statistically significant good agreement with regard to Hodgkin lymphoma (K 0.774, SE 0.07, 95% CI 0.606-0.882, p=0.001), non-Hodgkin lymphoma (K 0.640, SE 0.07, 95% CI 0.472-0.807, p=0.001), carcinoma (K 0.723, SE 0.069, 95% CI 0.528-0.918, p=0.001), and mycobacterial infection (K 0.726, SE 0.07, 95% CI 0.618-0.833, p=0.001).Ĭitation: Reddy DL, Venter WDF, Pather S (2015) Patterns of Lymph Node Pathology Fine Needle Aspiration Biopsy as an Evaluation Tool for Lymphadenopathy: A Retrospective Descriptive Study Conducted at the Largest Hospital in Africa. There were more cases of high-grade non-Hodgkin lymphoma in the HIV positive group compared to the HIV negative group. In this group, non-Hodgkin lymphoma and Hodgkin lymphoma constituted 9% and 8%, respectively. In contrast, the most common lymph node pathologies in HIV negative patients were nonspecific reactive lymphoid hyperplasia (45%), carcinoma (25%) and Mycobacterial infection (11%). The most common lymph node pathologies in HIV positive patients were Mycobacterial infection (31%), HIV reactive nodes (15%), non-Hodgkin lymphoma (15%) and nonspecific reactive lymphoid hyperplasia (15%). 27% were HIV negative and in the remaining nodes, the HIV status of patients was unknown. HIV positive patients constituted 49% of this study sample and the majority (64%) of this subset had CD4 counts less than 350 cells/ul. ![]() The co-existing pathologies were TB and Castleman disease. Concomitant lymph node pathology was diagnosed in four cases of nodal KS (29% of the subset). Kaposi sarcoma (KS) accounted for 2.5% of lymph node pathology in this sample. 22% of the total sampled nodes displayed necrotizing granulomatous inflammation (including histopathology and cytology demonstrating definite, and suspicious for mycobacterial infection), 8% comprised HIV reactive nodes in the remainder no specific pathology was identified (nonspecific reactive lymphoid hyperplasia). Overall, malignancy constituted the largest biopsy pathology group (39%), with 36% of this group being carcinoma and 27% non-Hodgkin lymphoma. The most common indication for biopsy was an uncertain diagnosis (more than two differential diagnoses entertained), followed by a suspicion for lymphoma, carcinoma and TB. The median age of patients was 40 years (range12–94). The majority of patients were female (55%) and of the African/black racial group (90%).
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